January 29, 2023

Scientists say there is no reason to panic about delta mutations

Don Joslin, a firefighter working with intensive care nurses in the intensive care unit at Queen Alexandra Hospital in Portsmouth, South England, assists a masked Govt-19 patient.

Adrian Tennis | AFP | Getty Images

LONDON – A sub-variant of the recently discovered Covit-19 delta strain now makes up 10% of new UK cases – but scientists say there is no reason to panic.

Also known as AY.4.2, there are some concerns about it May be more than 10% contagious Than the original Delta strain, but there is not yet enough evidence to prove that this is so.

The subtype – thought to have appeared in the UK in the summer – has two additional mutations that affect its spike protein, which is part of the structure of the virus used to infiltrate cells. Questions still linger about how, or, how quickly those mutations spread.

Over the past 28 days, AY.4.2 accounted for about 10% of new Govt-19 cases, according to data from the Cog-UK Public Health Association. It remains the UK’s third dominant version of the Covit-19 for the past four weeks after being called the original Delta Strain and its sublimations.

Despite its increase, public health officials in the UK have so far emphasized that AY.4.2 does not appear to cause the most serious disease or that existing vaccines are less effective. And step Biologists at the University of Northampton, England, Mutation failed to catch on in many European countries, “Radar dropped in Germany and Ireland.”

Christina Bagel, director of the Clinical Operations Research Unit at University College London, told CNBC that although Delta’s new subtype is certainly growing in the UK and elsewhere, it is not a big reason for warning.

“It looks like it has a 12% and 18% transmission gain over Delta, so that’s not good news in that respect. It makes things a little harder, but it’s not a big jump,” Begel said.

“The delta was 60% more permeable compared to the alpha, doubling it every week. It’s increasing by a percentage point or two per week – it’s very slow. So, in that sense, it’s not a big disaster like the delta. It’s going to change the delta gradually over the next few months. But this is no sign of over-vaccination resistance. [so] I do not think so.

However, the appearance of the new mutation raised some concerns, Begel said. He added that if a new mutation occurs in countries lagging behind the UK in vaccination programs, it will create additional problems. It has also been proven that the corona virus is still changing.

“There are different subtypes of delta, [but] This is the first subspecies that really seems to have an advantage over other deltas, “Begel said.” And it shows that there is more room for it to go and evolve. Some say Delta is a sweet spot hit – look, it’s another sweet spot. “

Bagel called for the re-introduction of some mitigation measures in the UK, which were scrapped All its remaining Govt controls July and is now one of the highest infection rates in the world.

“If you have more case numbers, you continue to offer opportunities for mutation,” he said. “I do not think it’s a coincidence [the new subvariant] Has come to the UK, where we have more cases for a long time. “

Importance of vaccination

David Mathews, a professor of virology at the University of Bristol, told CNBC in a phone call that booster vaccines and vaccines could help children slow down the rapid release of the virus, with the UK focusing on 10% of adults. Still refused the vaccine.

“Vaccine or not, everyone will catch this virus one day,” Matthews warned. “So the only question you have to ask yourself is: Do you want to meet this vaccine with someone whose immune system is trained or not trained to fight?”

He added: “What Delta Variation does, and what AY.4.2 does, is to quickly find those who have not been vaccinated. So if you’m not vaccinated, the time it takes before the virus finds you is reduced each time.

Variations ‘The Truth of Life’

Iyal Leshem, Infectious Disease Specialist, Sheba Medical Center, which treats Israel’s leading patients, AY.4.2.

“A.4.2 has been in circulation in the UK for some time now and it has not yet generated more than 10% of cases,” he said. “Delta, once in circulation, became a completely dominant variant within several weeks. This went unnoticed with AY.4.2.”

Leshem added that variations are “the truth of life” when it comes to the most infectious viruses.

“People all over the world cannot be fully vaccinated to prevent the virus from spreading with the intention of eradicating it, so if variations are not made in the UK, they will be made elsewhere,” he told CNBC by phone. .

“I don’t think new variations are important when deciding whether or not to open a country fully – I think the UK has made the right choice. [to reopen]. “