Due to the expansion of the mortality rate SARS – Cove-2 It does not stop at the world; Even the rise in epidemics has forced the governments of many European countries to re-imprison themselves. Despite the application Vaccines offered by reputed laboratories are an urgent need for new therapies that are a complementary support of drugs in this health struggle.
A team of scientists from the Pearlman School of Medicine at the University of Pennsylvania (United States) discovered nine skills Drugs To fight COVID-19 They are inhaled antivirals, seven of which have previously been used in humans, and three have been approved by the U.S. Food and Drug Administration (FDA).
All the details of this new discovery have been accumulated in the journal Science Cell reports.
Experts have made estimates of African green monkey kidney epithelial cells because “they are commonly used for proliferation SARS – Cove-2. Similarly, later, they mimicked experiments in human cells.
To be more precise in their research, the study signatories created a library with 3,059 drugs. 1,000 of them are approved by the FDA. “In addition, we purchase drugs with SARS-CoV-2 activity (e.g., remdecivir, lobinavir, azithromycin, etc.),” the introductory section states.
With respect remdesivir, A prototype for intravenous and oral administration, has been shown to be effective against SARS-CoV-2 in vitro and “have promising results in clinical trials”.
However, Hydroxy chloric, approved for use against malaria, shows little efficacy, so its distribution in these infections is not recommended.
They also looked for a type of respiratory cell that could be infected with SARS-CoV-2. They discovered what is called foot-3. They thus check the validity of antiviral compounds and remove potential candidates one by one. Medicine.
According to a study by Cell Reports, this is a list of nine anti-COVID drugs:
- Salinomycin: An antibiotic and chemotherapy drug
- Y-320: An immunomodulator
- Epastin: Used for allergic disorders, especially in Asia
- AZD8055: SARS-CoV-2 antivirals in Hu-7 and leg-3 cells
- Bemsentinip: A promising inhibitor only in early infections
- Dacomycin: a powerful antiviral in leg-3 cells
- WYE-125132: Similar al AZD8055
- Dp44mT: Metabolic regulator
- Cyclopilin: A type of immunosuppressant that binds to cyclosporine-binding proteins, rejecting transplanted organs.
“There may be significant benefits in the use of cyclosporine in hospitalized patients COVID-19, And ongoing clinical trials in Penn and elsewhere test that hypothesis, ”said Ph.D. Sarah Cherry, professor of pathology and laboratory medicine, and co-author of the study.
At the end of the scientific paper, the panel recommended that “additional trials be conducted to determine the effectiveness of these antiviral drugs for COVID-19 patients, and with that protection” report future treatment strategies. “
Johns Hopkins University, events through its interactive map Corona virus Worldwide, as of Saturday, April 3, more than 130.6 million people had been affected and more than 2.8 million had died.